Early diagnosis of different type of dementia through MRI. Lead Investigator: Qun Yu Institution : Sun Yat-Sen University E-Mail : yuqun3@mail2.sysu.edu.cn Proposal ID : 1422 Proposal Description: Goal: Early diagnosis of different type of dementia through MRI. Expected outcomes: Before the typical symptoms appear, different type of dementia shows characteristic atrophy patterns through MRI. Objective: By using a more precise brain segmentation software, AccuBrain, and Designing a reasonable calculation formula, we look forward to early diagnose different type of dementia through MRI. The study aims to investigate the different atrophy patterns and differential diagnosis in several dementing neurodegenerative disorders via MRI. The main variables of interest: Age, initial visit Sex Race Years of education Global score, initial visit Cognitive status, initial visit, Primary clinical diagnosis, initial visit At least one MRI available for download ? by scan type. Main outcomes of interest: Volume of different brain tissues e.g. hippocampus, amygdaloid nucleus, thalamus, etc.